AG 957, Adamantyl Ester (C007B-019803)

AG 957, Adamantyl Ester is a lipophilic, adamantyl ester form of tyrphostin AG 957 that displays anti-proliferative properties. The product has been shown to be selective and is ~3-4 fold more potent than the bcr/abl kinase inhibitor AG 957. AG 957, Adamantyl Ester Downregulates p210bcr/abl autokinase activity (IC|50|= 14 µM). Selectively blocks granulocyte colony formation in CML (chronic myelogenous leukemia) progenitors and inhibits proliferation of K562 cells (IC|50|= 9.8 µM) by inducing apoptosis. AG 957, Adamantyl Ester is reported to retain activity in STI571-resistant and p53-null human leukemia cell lines (IC|50|~0.1-0.25 µM).AG 957, Adamantyl Esteris an ~3-4 fold more potent derivative of AG 957. Specification: 0.98 Molecular Formula: C24H27NO4 Molecular Weight: 393.48 PubChem CID: 387042 Isomeric SMILES: C1C2CC3CC1CC(C2)(C3)OC(=O)C4=CC=C(C=C4)NCC5=C(C=CC(=C5)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A387504-SCI_c686bd409657a36574ed29fa7745c542.pdf

UPC:

12352200

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A387504-25mg

CAS:

241127-58-2

Product Size:

25mg

Precautionary Statement Codes:

P264