Aladdin-1

Potent and selective NOP agonist

SC-43, a sorafenib derivative, is an agonist ofSrc-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6)and reduces liver fibrosis. SC-43 reducesp-STAT3and inducesapoptosiswith anti-tumor activity.

SBFI-26

SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.

SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.

SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD). p38 MAPK inhibitor

Store at +4°C. Store under desiccating conditions.

SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively.

5-HT2B/5-HT2C receptor antagonists

ATP citrate lyase (ACLY) inhibitor

SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of5-HT2B/2Cover 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.

SAR7334 SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.