Aladdin-1

TCO-PEG8-acid is a non-activated PEG derivative containing a TCO moiety and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.

TCO-PEG4-DBCO is a reagent containing a TCO and a DBCO moiety. TCO group specifically and efficiently reacts with terrahydrazine.

TCO-PEG2-TCO is a reagent containing TCO moiety at both ends of the molecule. TCO group specifically and efficiently reacts with terrahydrazine.

TCO-PEG12-NHS Ester is a PEG derivative containing a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water-solubility and a decreases steric hindrance during ligation.

TCO PEG maleimide is a sulfhydryl reactive, pegylated TCO (transcyclooctene) derivative that can react with tetrazine group. Maleimide reacts with sulfhydryl groups (thiol, -SH) groups at neutral pH efficiently.

TCO PEG Fluorescein, TCO-PEG-FITC

TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors.

Potent and selective PI 3-kinase δ inhibitor

Potent and selective V1Breceptor antagonist

TAK-243 (MLN7243) TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay.

T532

T-26c T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes.