AMINOPTERIN POWDER (C005B-048013)

Biochem/physiol Actions

Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

Features and Benefits

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Linkage

More potent, but more toxic, than methotrexate.

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UPC:

12352200

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

Quantity:

100

Unit of Measurement:

MG

MPN:

A1784-100MG

CAS:

54-62-6

Temperature Control Device:

Yes