Angeli′s salt

A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.A nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli′s Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.

a NO donor salt with demonstrated cytotoxicity

Specifications & Purity: A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.A nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli′s Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.

Molecular Formula: N2O3•2Na

Molecular Weight: 121.99

PubChem CID: 10129945

Isomeric SMILES: N(=O)[N+](=O)[O-].[Na+].[Na+]

Storage Temperature: Store at -20°C;Argon charged

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A332354-SCI_241e9bbde8e471acf813ec536ea4fc65.pdf

UPC:

51191800

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A332354-5mg

Country of Origin:

China

CAS:

13826-64-7

Product Size:

5mg

Harmonized Tariff Code:

2931.90.90

Precautionary Statement Codes:

P264