Angelic Acid

Angelica acid is a ferroptosis inducer targeting NRF2. It binds to the NRF2 protein and promotes its degradation via the ubiquitination-proteasome pathway, relieving the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation, inducing ferroptosis in tumor cells, enhancing intracellular reactive oxygen species (ROS) accumulation, upregulating ferroptosis-related markers CHAC1 and PTGS2, and synergistically enhancing antitumor effects with ferroptosis inducers. It also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation, and also helps wound healing and has pro-sedative activity.

Specifications & Purity: Angelica acid is a ferroptosis inducer targeting NRF2. It binds to the NRF2 protein and promotes its degradation via the ubiquitination-proteasome pathway, relieving the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation, inducing ferroptosis in tumor cells, enhancing intracellular reactive oxygen species (ROS) accumulation, upregulating ferroptosis-related markers CHAC1 and PTGS2, and synergistically enhancing antitumor effects with ferroptosis inducers. It also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation, and also helps wound healing and has pro-sedative activity.

Grade: Moligand™

MDL Number: MFCD00002654

Molecular Formula: C5H8O2

Molecular Weight: 100.12

EC Number: 209-284-2

PubChem CID: 643915

Isomeric SMILES: C/C=C(/C)\C(=O)O

Beilstein: 2(4)1551

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B137277-SCI_64a0a68d417d023d0e886f42cc968775.pdf

UPC:

51191546

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B137277-250mg

Country of Origin:

China

CAS:

565-63-9

Product Size:

250mg

Harmonized Tariff Code:

2931.90.90

Health Hazards:

Corrosive

Hazard Statement Codes:

H290;H314;H318

Precautionary Statement Codes:

P234;P260;P264;P280;P321;P363;P390;P301+P330+P331;P304+P340;P405;P406;P501;P264+P265;P305+P354+P338;P317;P302+P361+P354;P316