General description
Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
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- UPC:
- 51432811
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 176708-250UG
- Temperature Control Device:
- Yes
