ANGIOSTATIN K1-3 HUMAN REC 1PC X 250UG

General description

Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀=70 nM) relative to kringles 1-4 (ED₅₀=135 nm).

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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UPC:

51432811

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

250

Unit of Measurement:

UG

MPN:

176708-250UG

Temperature Control Device:

Yes