ANISOMYCIN FROM STREPTOMYCES GRISEOLUS (C005B-026287)

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH₂ terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

Caution

Hygroscopic

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UPC:

51281674

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

Quantity:

100

Unit of Measurement:

MG

MPN:

A9789-100MG

CAS:

22862-76-6