ANTI-AURA ANTIBODY PRODUCED IN RABBIT

General description

AURA/AURKA (aurora kinase A) is mapped on to human chromosome 20q13.2. It is also termed as STK15 (serine/threonine kinase 15). This gene codes for a protein of 403 amino acids with regulatory and catalytic domains.

Immunogen

The antiserum was produced against synthesized peptide derived from human AurA.

Immunogen Range: 311-360

Biochem/physiol Actions

AURA/AURKA (aurora kinase A) modulates cell cycle checkpoints and plays important roles in centrosome division, cytoskeleton and cytokinesis. It sustains the integrity of chromosome after DNA damage. The catalytic domain of AURKA possesses a serine/threonine kinase activity role. It is overexpressed in several malignancies like invasive carcinomas of ovary, head, neck and breast.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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UPC:

41181879

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

MPN:

SAB4502887-100UG

Temperature Control Device:

Yes

Controlled Substances and Cyanide:

Yes