ANTI-CD45 ANTIBODY PRODUCED IN RABBIT (C005B-318541)

General description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1057-1306 of human CD45 (NP_002829.3).

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

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UPC:

51201623

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

MPN:

SAB5700873-100UL

Temperature Control Device:

Yes

Controlled Substances and Cyanide:

Yes