General description
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Variations in the expression of laminins have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. Laminins have been provoked by the discovery of their ability to promote neurite regeneration. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively). The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.
Immunogen
Basement membrane protein preparation from mouse EHS tumor.
Application
Detect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).
Research Sub Category
ECM Proteins
Adhesion (CAMs)
Target description
177 kDa
Physical form
Format: Purified
Purified rat immunoglobulin in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Analysis Note
Control
Tubular carcinoma of the colon and fibroneuroma
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
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- UPC:
- 41106514
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- MAB1914P
- Temperature Control Device:
- Yes
- Controlled Substances and Cyanide:
- Yes
