ANTI-TRANSCRIPTION FACTOR E3 ANTIBODY PRODUCED IN CHICKEN

Immunogen

Immunogen Sequence: GI # 8659574, sequence 432-541

Recombinant transcription factor binding to IGHM enhancer 3

Application

Anti-Transcription Factor E3 antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

Biochem/physiol Actions

TFE3 (Transcription factor E3) gene encodes a helix-loop-helix transcription factor that contains a helix-loop-helix domain and binds to MUE3-type E-box sequences (5′-CANNTG-3′). It plays a key role in transforming growth factor β (TGF-β) induced activation of the plasminogen activator inhibitor-1 (PAI-1) promoter. Chromosomal translocation resulting in the fusion of TFE3 gene to a novel gene, designated PRCC, is observed in papillary renal cell carcinomas. A chromosomal aberration in TFE3 is observed in patients with alveolar soft part sarcoma.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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UPC:

12352200

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

50

Unit of Measurement:

UG

MPN:

GW20056A-50UG

Temperature Control Device:

Yes

Controlled Substances and Cyanide:

Yes