ARQ 621 (C007B-020974)

InformationARQ 621 ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.TargetsEg5 mitotic motor proteinIn vitroARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells.In vivoARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. Specification: 0.96 Molecular Formula: C28H24Cl2FN5O2 Molecular Weight: 552.43 PubChem CID: 25110841 Isomeric SMILES: C#CC[C@H](C1=NC2=C(C=CC(=C2)Cl)C(=O)N1NC3=CC=CC=C3)N(CCCN)C(=O)C4=C(C(=CC=C4)Cl)F

UPC:

51111756

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No;ManufacturerName=Aladdin Scientific"

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A413746-25mg

CAS:

1095253-39-6

Product Size:

25mg

Controlled Substances and Cyanide:

Yes