AS601245 (C007B-016400)

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.product description：A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration. Biochemical mechanism:Cell permeable: yesProduct competes with ATP.Primary TargethJNK 1, hJNK 2, hJNK 3Reversible: yesTarget IC50: 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively. Specification: ≥95% Molecular Formula: C20H16N6S Molecular Weight: 372.45 PubChem CID: 10109823 Isomeric SMILES: C1=CC=C2C(=C1)N=C(S2)C(C#N)C3=NC(=NC=C3)NCCC4=CN=CC=C4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A275935-SCI_7db1a69b61975563f1d6d65b99b81bf2.pdf

UPC:

51151629

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A275935-25mg

CAS:

345987-15-7

Product Size:

25mg

Hazard Statement Codes:

H302:H315:H319:H332

Precautionary Statement Codes:

P261:P264:P270:P271:P280