Ascomycin, 100 mg

Synonyms: Immunomycin, FK520, FR-900520 Ascomycin is a macrolide immunosuppressant antibiotic. It is an ethyl analog of FK506. Ascomycin binds to the FK-506-binding protein FKBP12 and blocks the peptidyl-prolyl cis-trans isomerase activity of the protein. This bound complex inhibits calcineurin phosphatase in the nM range, consequently suppressing the presentation of Th1 and Th2-type cytokines in cells and reducing production of interleukins IL-2, 4, and 10, leading to immunosuppression. Pimecrolimus, an Ascomycin derivative, has been shown to block the release of allergic response mediators from mast cells. Warning: For laboratory use only. Not fit for agricultural, household, clinical use or human consumption. Density:1.19 g/cm3 Melting Point: 153-157°C Boiling Point: 868.3°C at 760 mmHg Flash Point: 478.9°C Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate, chloroform; slightly soluble in n-hexane and petroleum ether; insoluble in water.

Shipping Information:

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UPC:

51202601

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

40110044-2

CAS:

104987-12-4/11011-38-4