Sigma-Aldrich
ATR-101 (C005B-310089)
Biochem/physiol Actions ATR-101 (PD 132301-02: Nevanimibe HCl) is an orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior (IC 50 = 52 nM: intestinal microsome from cholesterol-fed rabbits) that
Description
Biochem/physiol Actions
ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) that reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed rat models. In addition, ATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH), and Cushing′s syndrome (CS).
Specifications
- UPC:
- 51321709
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- Quantity:
- 5
- Unit of Measurement:
- MG
- MPN:
- SML2802-5MG
- CAS:
- 133825-81-7
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