General description
A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitor that contains the Antennapedia transport peptide sequence fused to the amino terminus of AIP-II (Cat. No. 189484).
A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala3 and Val10 are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala286) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cam Kinase-2
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Watterson, D.M., et al. 2001. Neurochem. Int.39, 459.
Ishida, A., et al. 1998. FEBS Lett.427, 115.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 12352202
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 189485-1MG