Axitinib (C007B-006020)

Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β.An inhibitor of Flt and Flk (VEGFR) with antitumor properties Application： Axitinib has been used as a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (TKI) to study its effect on renal cancer cell proliferation in vitro. It has also been used to inhibit anterior mesenteric artery (AMA) angiogenesis in dechlorinated embryos maintained in conditioned water (CW). Specification: ≥99% MDL Number: MFCD09837898 Molecular Formula: C22H18N4OS Molecular Weight: 386.47 PubChem CID: 6450551 Isomeric SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A129732-SCI_2f25f9edcaffa91614cb2902166d42e0.pdf

UPC:

51111833

Condition:

New

Weight:

0.97 Ounces

HazmatClass:

No

WeightUOM:

LB

MPN:

A129732-50mg

CAS:

319460-85-0

Product Size:

50mg

Hazard Statement Codes:

H302

Precautionary Statement Codes:

P260:P264:P270:P273:P280:P281:P330:P391:P301+P312:P405:P501