AZ82 (C007B-325300)

AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a K i of 43 nM and an IC 50 of 300 nM for KIFC1.In VitroAZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC 50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:HSET/KIFC1|300 nM (IC|50|)|HSET/KIFC1|43 nM (Ki). Specification: 0.99 Molecular Formula: C28H31F3N4O3S Molecular Weight: 560.64 PubChem CID: 91885438 Isomeric SMILES: CCCC1=C(SC(=C1)C(=O)N[C@H](CC2=CN=C(C=C2)C3=CC(=CC=C3)OC(F)(F)F)C(=O)N[C@@H]4CCNC4)C

UPC:

51202411

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A648582-25mg

CAS:

1449578-65-7

Product Size:

25mg