AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a K i of 43 nM and an IC 50 of 300 nM for KIFC1.In VitroAZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC 50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:HSET/KIFC1|300 nM (IC|50|)|HSET/KIFC1|43 nM (Ki). Specification: 10mM in DMSO Molecular Formula: C28H31F3N4O3S Molecular Weight: 560.64
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A655482-1ml
- CAS:
- 1449578-65-7
- Product Size:
- 1ml
