AZURIN FROM PSEUDOMONAS AERUGINOSA

Application

Azurin has been used:

• in the cytotoxicity and cell viability studies in human osteosarcoma cell line
• for the functionalization of silicon nitride cantilevers for interaction studies
• for coating gold surface and insulating functionalized oxide surfaces of silicon oxide and mica

Biochem/physiol Actions

Azurin is a metalloprotein in the family of cupredoxins. It preferentially enters cancer cells over normal cells and induces apoptosis. Azurin has structural similarities to ephrinB2, and in fact binds the ephrin receptor tyrosine kinase EphB2 to initiate cell signaling that is involved in cancer progression. Azurin inhibits autophosphorlyation of the EphB2 tyrosine residue, interfering with upstream cell signaling and contributing to cancer cell growth inhibition.

Physical form

Lyophilized powder containing ammonium acetate buffer salts.

UPC:

51284301

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

MG

MPN:

A3672-1MG

CAS:

12284-43-4

Controlled Substances and Cyanide:

Yes