Balixafortide TFA

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arreAppearance:SolidIC50& Target:CXCR4 <10 nM (IC 50 )In Vitro:Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC 50 < 200 nM) and Jurkat (IC 50 < 400 nM). Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC 50 < 20 nM), Namalwa and JuIn Vivo:Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability. MCE has not independently confirmed the accuracy of theBiological Activity:Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arre

Specifications & Purity: Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arreAppearance:SolidIC50& Target:CXCR4 <10 nM (IC 50 )In Vitro:Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC 50 < 200 nM) and Jurkat (IC 50 < 400 nM). Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC 50 < 20 nM), Namalwa and JuIn Vivo:Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability. MCE has not independently confirmed the accuracy of theBiological Activity:Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arre

Grade: Moligand™

Molecular Formula: C84H118N24O21S2(free base)

Molecular Weight: 1864.11(free base)

Storage Temperature: Protected from light;Store at -20°C;Argon charged

Shipped in: Ice chest + Ice pads

UPC:

51433703

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B658810-1mg

Country of Origin:

China

CAS:

1051366-32-5

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90