BI-671800

BI-671800 BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.Targetsmurine CRTH2 (Cell-free assay); human CRTH2 (Cell-free assay) 3.7 nM; 4.5 nM

Prostaglandin Receptor Antagonists

Specifications & Purity: BI-671800 BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.Targetsmurine CRTH2 (Cell-free assay); human CRTH2 (Cell-free assay) 3.7 nM; 4.5 nM

Molecular Formula: C25H26F3N5O3

Molecular Weight: 501.5

PubChem CID: 45270144

Isomeric SMILES: CN(C)C1=C(C(=NC(=N1)CC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)C(F)(F)F)N(C)C)CC(=O)O

Storage Temperature: Protected from light;Store at -20°C

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B412421-SCI_fce6944e034cb59842f3ec1489d22e36.pdf

UPC:

51442703

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B412421-1mg

Country of Origin:

China

CAS:

1093108-50-9

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90