Calcium Signaling Agents

Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2. Also suitable for measuring the peptidase activity of the 20S proteasome.

A fluorogenic FRET peptide with a substrate sequence that is optimized for calpain-1 and -2 based on 106 known cleavage sites. It is cleaved by mammalian calpains with a much better efficacy (k cat /K m x10 -2 (M -1 s -1 ) = 69.

An internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides. Shown to be kinetically superior, in terms of turnover rate, to Calpain Substrate III, Fluorogenic

An internally quenched fluorogenic substrate peptide derived from the calpain-1 cleavage site of &#945-spectrin. It is not recognized by trypsin or &#945-chymotrypsin and serves as a sensitive and specific substrate for calpain-1 (K m = 4.

A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells.

A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells.

Biotinylated derivative of Caspase Inhibitor I (Cat. No.

A potent and reversible inhibitor of caspases. A potent and reversible pan-caspase inhibitor.

A broad-spectrum cell-permeable and irreversible caspase inhibitor. A cell-permeable, irreversible, broad-spectrum caspase inhibitor.

A broad-spectrum cell-permeable and irreversible caspase inhibitor. A cell-permeable, irreversible, broad-spectrum caspase inhibitor.

A potent, specific, and reversible inhibitor of caspase-1 (K i = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

A potent, specific, and reversible inhibitor of caspase-1 (K i = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.