BL 1249

BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). Application：BL-1249 has been used:as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissuesas a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell lineas a TREK1 and TREK2 activator in mice.

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Specifications & Purity: BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). Application：BL-1249 has been used:as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissuesas a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell lineas a TREK1 and TREK2 activator in mice.

Grade: Moligand™

Molecular Formula: C17H17N5

Molecular Weight: 291.35

EC Number: 634-043-7

PubChem CID: 16078951

Isomeric SMILES: C1CCC2=C(C1)C=CC=C2NC3=CC=CC=C3C4=NNN=N4

Storage Temperature: Protected from light;Store at -20°C;Argon charged

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B286784-SCI_89961351d05460e42b3755665f067276.pdf

UPC:

51373327

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B286784-1mg

Country of Origin:

China

CAS:

18200-13-0

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90

Hazard Statement Codes:

H315;H319;H335;H413

Precautionary Statement Codes:

P261;P264;P271;P273;P280;P321;P302+P352;P304+P340;P305+P351+P338;P362+P364;P405;P403+P233;P501;P264+P265;P337+P317;P332+P317;P319