BMS-1166 hydrochloride (C007B-336086)

BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1 , with an IC 50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activationIn VitroBMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC 50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 1.4 nM (PD-1/PD-L1 interaction). Specification: 0.99 Molecular Formula: C36H34Cl2N2O7 Molecular Weight: 677.57 PubChem CID: 139035005

UPC:

51131620

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B649044-5mg

CAS:

2113650-05-6

Product Size:

5mg