Brequinar sodium (C007B-060920)

A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM). Specification: 0.98 Molecular Formula: C23H14F2NNaO2 Molecular Weight: 397.35 PubChem CID: 23663964 Isomeric SMILES: CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)[O-].[Na+] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B287474-SCI_3a075d5d20df28637b873aaca41986be.pdf

UPC:

51112203

Condition:

New

Weight:

0.97 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B287474-100mg

CAS:

96201-88-6

Product Size:

100mg

Hazard Statement Codes:

H302:H315:H319:H335

Precautionary Statement Codes:

P261:P305+P351+P338