Butyzamide (C007B-335968)

Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assayIn VitroButyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells. Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34 + hematopoietic progenitor cellls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoButyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34 + cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:JAK2 STAT3 STAT5. Specification: 0.99 Molecular Formula: C29H32Cl2N2O5S Molecular Weight: 591.55

UPC:

12352202

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

B648013-10mg

CAS:

1110767-45-7

Product Size:

10mg