C-RAF INHIBITOR 1PC X 20MG (C005B-228261)

General description

A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC₅₀ value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI ₅₀ = 2.68 µM) and WM3629 (GI₅₀ = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.

A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC₅₀ value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI ₅₀ = 2.68 µM) and WM3629 (GI₅₀ = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 480.45. Empirical Formula: C₂₃H₁₉F₃N₈O. Quality Level: 100. Assay: ≥. 95% (HPLC). form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze. color: off-white. solubility: DMSO: 10 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

UPC:

51112000

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

20

Unit of Measurement:

MG

MPN:

475958-20MG