CA-074 1PC X 1MG

General description

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC₅₀ = 2.24 nM for rat liver cathepsin B).

An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC₅₀ = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).

Biochem/physiol Actions

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.24 nM for rat liver cathepsin B

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem.121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

12352200

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

MG

MPN:

205530-1MG