CA3 (CIL56) (C007B-101537)

InformationCA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependIn vitroCA3 strongly inhibits esophageal adenocarcinoma cell growth in vitro. CA3 can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells. CA3 specially inhibits Tead/YAP1 transcriptional activity but shows no inhibitory activity on other transcriptional factors-Super-TOP/Wnt, CBF1/Notch, and AP-1 after cotransfection of their respective individual promoter luciferases in 293T cells. CA3 preferentially inhibits CSC properties enriched in radiation-resistant esophageal adenocarcinoma cells.In vivoCA3 exerts strong antitumor activity in xenograft model with no apparent toxicity.Cell Datacell lines：Concentrations：0.5 and 1 μmol/LIncubation Time：48 hoursPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C23H27N3O5S2 Molecular Weight: 489.61

UPC:

51172815

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C408494-1ml

CAS:

300802-28-2

Product Size:

1ml