CALMODULIN INHIBITORY PEPTIDE - CALBIOCHEM

General description

A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (K_d = 6 pM).

A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (K_d = 6 pM). Inhibits calmodulin activation of MLCK-catalyzed phosphorylation of smooth muscle regulatory light chain(MLC).

Biochem/physiol Actions

Cell permeable: no

Kd = 6 pM in binding to calmodulin

Primary Target
Calmodulin

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Torok,K., et al. 1998. Biochemistry 37, 6188.
Török, K., and Trentham, D.R. 1994. Biochemistry33, 12807.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

51262302

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

500

Unit of Measurement:

UG

MPN:

208735-500UG

Controlled Substances and Cyanide:

Yes