CASPASE-8 INHIBITOR II - CALBIOCHEM (C005B-098097)

General description

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

Analysis Note

≥98% (HPLC)

Other Notes

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

51202800

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

MG

MPN:

218759-1MG