CDK9-IN-7 (C007B-343402)

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor ( IC 50 =11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis , arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLCIn VitroCDK9-IN-7 displays exceptional potency against NSCLC cell lines, especial A549 and H1299 with IC 50 values less than 0.5 µM. In the drug-resistant NSCLC cell line H1975, CDK9-IN-7 also exhibits good inhibition potency with an IC 50 value of 0.837 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:CDK9/cyclinT1 11 nM (IC 50 ) CDK4/cyclin D 148 nM (IC 50 ) CDK6/cyclinD 145 nM (IC 50 ). Specification: 0.99 Molecular Formula: C29H37N7O2S Molecular Weight: 547.71 PubChem CID: 138911336 Isomeric SMILES: CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)NC(=O)CCCCCCCN=C=S

UPC:

51112203

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C650913-10mg

CAS:

2369981-71-3

Product Size:

10mg