CE-245677 (C007B-342421)

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 s of 4.7 and 1 nM.In VitroCE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoCE-245677 shows good oral absorption in in vivo rat PK studies (F=80%) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:TrkA Tie2 4.7 nM (IC 50 ). Specification: 0.98 Molecular Formula: C24H22Cl2N6O3 Molecular Weight: 513.4 PubChem CID: 16048643 Isomeric SMILES: CC(C)N1C=C(C2=C(N=CN=C21)N)C(=O)C3=CC(=C(C=C3)OC)NC(=O)NC4=C(C=C(C=C4)Cl)Cl

UPC:

51111717

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C646954-10mg

CAS:

717899-97-3

Product Size:

10mg