Antibody Labeling and Modification Kits

The CD7 antigen is a membrane-bound 40 kDa glycoprotein expressed on thymocytes, mature T cells, a large majority of natural killer cells, pluripotent hematopoietic stem cells, and progenitor cells of lymphoid and myeloid cells (Bowen, 2002 and

CD71 is a 190 kDa disulfide-bonded homodimeric type II transmembrane glycoprotein. CD71 is the receptor for transferrin.

CD79 is a disulphide-linked transmembrane heterodimer with a molecular mass of 82-95 kDa belonging to the immunoglobulin superfamily. It comprises the two glycoproteins, CD79&#945, with a molecular mass of 40-45 kDa, and CD79&#946, with a

CD79beta is restricted to the B-cell lineage, and is found in pro-B cells before Ig heavy-chain gene rearrangement but after CD79alpha expression. The antibody reacts with an epitope on the extracellular domain of CD79 (Yoshida, 1995).

CD8 is a 68 kDa disulphide-linked, transmembrane glycoprotein. The CD8 molecule serves as a receptor for MHC class I molecules and can mediate a function as a coreceptor in TCR-ligand binding and T-cell activation.

Collagens are highly conserved throughout evolution and are characterised by an uninterrupted Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon."

MAP-2 (microtubule associated protein-2) is one of several high molecular weight proteins that play an important role in brain neuron microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the &#8242beads on

Nestin, a large intermediate filament protein (class Type VI) expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18.

There are 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The five major classes of histones are H1/H5, H2A, H2B, H3, and H4.

Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common

ATRX (&#945-thalassemia/mental retardation syndrome X-linked) is encoded by the gene mapped to human chromosome Xq21.1.