Complement

Native, human C3b complement component. Cleavage of the C3-&#945 chain at peptide bond 77 by either of the complement C3 convertase enzymes results in production of C3a (M.

Complement C4 is mapped to human chromosome 6p21.33.

Native, human C4 complement component. Glycoprotein composed of three non-identical subunits of M.

Biochem/physiol Actions Complement C4b fragment is formed by the cleavage of the C4 α-chain by activated C1 enzyme. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces.

Application Complement C5 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp . (such as meningitis).

Application Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex

Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.

Human serum depleted of complement component C5 by affinity chromatography. Human serum that has been depleted of complement component C5 by affinity chromatography.

Native, human des-Arg C5a complement component. Single chain glycopeptide composed of 73 amino acids.

Native, human C5b,6 complement component complex. Activation of complement by either pathway results in the formation of C5-cleaving enzymes (C5 convertases) on target surfaces.

Application Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C6 may result in an increased susceptibility to Neisseria meningitidis .

Application Complement C7 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis).