Ciforadenant (CPI-444) (C007B-102638)

InformationCiforadenant (CPI-444) Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.TargetsA2AR 3.54 nM(Ki)In vitroCPI-444 restores T-cell activation in vitro.In vivoCPI-444 treatment resulted in a similar inhibition of tumor growth in the B16F10 melanoma (100 mg/kg) and RENCA renal cell cancer syngeneic models (10 mg/kg). It enhances T-cell activation in both the periphery and tumor microenvironment. Specification: 10mM in DMSO Molecular Formula: C20H21N7O3 Molecular Weight: 407.43 PubChem CID: 44537963 Isomeric SMILES: CC1=CC=C(O1)C2=C3C(=NC(=N2)N)N(N=N3)CC4=NC(=CC=C4)CO[C@H]5CCOC5

UPC:

51262414

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C420891-1ml

CAS:

1202402-40-1

Product Size:

1ml