Ciliobrevin D

Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motorcytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocksHedgehog (Hh)signaling.Targetscytoplasmic dynein ; HedgehogIn vitroCiliobrevin D inactivate dynein in Sertoli cells. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the Sertoli cells in vitro. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. Ciliobrevin D also prevents spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation, and peroxisome motility in cultured cells.In vivoCiliobrevin D inactivate dynein in the testis. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the seminiferous epithelium illustrating there are cross talks between the two cytoskeletons in the testis.Cell Research(from reference)Cell lines：Sertoli cells Concentrations：15 µM, 30 µM Incubation Time：1 h

Hedgehog inhibitor

Specifications & Purity: Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motorcytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocksHedgehog (Hh)signaling.Targetscytoplasmic dynein ; HedgehogIn vitroCiliobrevin D inactivate dynein in Sertoli cells. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the Sertoli cells in vitro. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. Ciliobrevin D also prevents spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation, and peroxisome motility in cultured cells.In vivoCiliobrevin D inactivate dynein in the testis. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the seminiferous epithelium illustrating there are cross talks between the two cytoskeletons in the testis.Cell Research(from reference)Cell lines：Sertoli cells Concentrations：15 µM, 30 µM Incubation Time：1 h

Molecular Formula: C17H8Cl3N3O2

Molecular Weight: 392.62

PubChem CID: 136257953

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51112403

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C414481-1mg

Country of Origin:

China

CAS:

1370554-01-0

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90