Ciliobrevin D (C007B-102251)

InformationCiliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motorcytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocksHedgehog (Hh)signaling.Targetscytoplasmic dynein ; HedgehogIn vitroCiliobrevin D inactivate dynein in Sertoli cells. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the Sertoli cells in vitro. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. Ciliobrevin D also prevents spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation, and peroxisome motility in cultured cells.In vivoCiliobrevin D inactivate dynein in the testis. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the seminiferous epithelium illustrating there are cross talks between the two cytoskeletons in the testis.Cell Research(from reference)Cell lines：Sertoli cells Concentrations：15 µM, 30 µM Incubation Time：1 h. Specification: 0.98 Molecular Formula: C17H8Cl3N3O2 Molecular Weight: 392.62 PubChem CID: 136257953

UPC:

51111703

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C414481-5mg

CAS:

1370554-01-0

Product Size:

5mg