Cirsiliol

Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.In Vitro（for reference only）In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.  In Vivo（for reference only）In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone. Cell AssayNSCLC, NCI-H1299, NCI-H460, WI-26 VA4 and MRC-5 cell lines are exposed to a single dose of γ-rays. Cells are then treated with rhamnetin and cirsiliol (5, 10, 15, 20, 25 μM) dissolved in DMSO for 4 h. Form:SolidIC50& Target:5-Lipoxygenase

Flavonoids Flavones Phenols Polyphenols

Specifications & Purity: Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.In Vitro（for reference only）In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.  In Vivo（for reference only）In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone. Cell AssayNSCLC, NCI-H1299, NCI-H460, WI-26 VA4 and MRC-5 cell lines are exposed to a single dose of γ-rays. Cells are then treated with rhamnetin and cirsiliol (5, 10, 15, 20, 25 μM) dissolved in DMSO for 4 h. Form:SolidIC50& Target:5-Lipoxygenase

Grade: Moligand™

Molecular Formula: C17H14O7

Molecular Weight: 330.29

EC Number: 809-104-8

PubChem CID: 160237

Isomeric SMILES: COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)O)O)OC

Storage Temperature: Protected from light;Store at -20°C;Desiccated

Shipped in: Ice chest + Ice pads

UPC:

51433802

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C651477-1mg

Country of Origin:

China

CAS:

34334-69-5

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90

Hazard Statement Codes:

H302

Precautionary Statement Codes:

P264;P270;P330;P501;P301+P317