General description
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50 = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.
Biochem/physiol Actions
Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant
Primary Target
5-HT Transporter
Warning
Toxicity: Harmful (C)
Reconstitution
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51292019
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 5062380001
- CAS:
- 59729-32-7
