CITALOPRAM HYDROBROMIDE (C005B-051072)

General description

A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC₅₀ = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.

Biochem/physiol Actions

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Primary Target
5-HT Transporter

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

51292019

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

25

Unit of Measurement:

MG

MPN:

5062380001

CAS:

59729-32-7