Clozapine (C007B-101498)

InformationClozapine (HF 1854, LX 100-129) is an atypical antipsychotic drug by acting as a5-HTantagonist, used in the treatment of schizophrenia.In vitroClozapine (10, 20 mg/kg) significantly increases the number of Fos-positive neurons in the nucleus accumbens, medial prefrontal cortex and lateral septal nucleus. Clozapine induces zif268 but not c-fos mRNA in rat striatum, while Haloperidol induces c-Fos-like immunoreactivity in the caudate-putamen. Clozapine is more selective for D4 receptors compared to D2 receptors. Clozapine is a mixed but weak D1/D2 antagonist. Clozapine produces a marked facilitation (300-400%) of NMDA-evoked responses in a concentration-dependent manner with EC50 of 14 nM. Clozapine, but not haloperidol, produces bursts of excitatory postsynaptic potentials (EPSPs), which are blocked by glutamate receptor antagonists, suggesting that these EPSPs are the result of increasing release of excitatory amino acids. Clozapine is a full agonist at the muscarinic M4 receptor (EC50 = 11 nM), producing inhibition of forskolin-stimulated cAMP accumulation. Clozapine potently antagonizes agonist-induced responses at the other four muscarinic receptor subtypes.In vivoClozapine/xa0exhibits an "inverted-U" shaped dose-response/xa0curve, reversing the/xa0apomorphine-induced loss of prepulse/xa0inhibition/xa0(PPI) at low doses but not at high doses in the rats./xa0Clozapine/xa0decreases PPI independent of/xa0apomorphine/xa0treatment in the rats./xa0Cell Datacell lines：LNCaP cells, PC3 cellsConcentrations：Incubation Time：Powder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C18H19ClN4 Molecular Weight: 326.82

UPC:

51332703

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No;ManufacturerName=Aladdin Scientific"

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C408052-1ml

CAS:

5786-21-0

Product Size:

1ml

Controlled Substances and Cyanide:

Yes