COMPLEMENT C9 HUMAN

General description

Native, human C9 complement component. Single-chain glycoprotein present in normal human serum at 60 µg/ml. On activation of complement via either the classical or alternative pathway, formation of the C5b fragment initiates assembly of C5b-9 complement membrane attack complex (MAC) on target surfaces. Full lytic activity of MAC occurs only after binding of three to six C9 molecules to each C5b-8 complex.

Native, human C9 complement component. Single-chain glycoprotein present in normal human serum at 60 µg/ml. On activation of complement via either the classical or alternative pathway, formation of the C5b fragment initiates assembly of the C5b-9 complement membrane attack complex (MAC) on target surfaces. Full lytic activity of MAC occurs only after binding of three to six C9 molecules to each C5b-8 complex.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In PBS, pH 7.2, filtered through a 0.22 µm pore size filter.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Stanley, K.K., et al. 1985. EMBO J. 4, 375.
Biesecker, G. and Muller-Eberhard, H.J. 1980. J. Immunol. 124, 1291.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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UPC:

41181519

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

250

Unit of Measurement:

UG

MPN:

204910-250UG

CAS:

80295-59-6

Temperature Control Device:

Yes