CUDA-10 mg

Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively. In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPAR.delta. or PPARγ.

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UPC:

51321702

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No"

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

10007923-10

Model Number:

C835A85

Temperature Control Device:

Yes

CAS:

479413-68-8