CW069 (C007B-102054)

InformationCW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.TargetsHSET 75 μMIn vitroCW069 increases multipolar spindles in N1E-115 cells with supernumerary centrosomes without altering bipolar spindle morphology in normal human dermal fibroblast cells. CW069 inhibits growth in cancer N1E-115 cells with IC50 of 10 μM, but not in NHDF or primary human bone marrow cells.Cell Research(from reference)Cell lines：N1E-115 cells, NHDF and primary human bone marrow cells. Concentrations：~400 μM Incubation Time：72 hours. Specification: 0.99 Molecular Formula: C23H21IN2O3 Molecular Weight: 500.33 PubChem CID: 73427517 Isomeric SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)NC2=C(C=C(C=C2)I)C(=O)O)NCC3=CC=CC=C3 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C413741-SCI_f0bf3d3b00e216547b5b10c492075243.pdf

UPC:

41106514

Condition:

New

Weight:

0.97 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C413741-50mg

CAS:

1594094-64-0

Product Size:

50mg

Hazard Statement Codes:

H302:H315:H319:H335

Precautionary Statement Codes:

P261:P305+P351+P338