CXCR2-IN-1 (C007B-343706)

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC 50 of 9.3.In VitroCXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 (compound 22) shows favorable central nervous system penetration property (Br/Bl>0.45). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoCXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:CXCR2 9.3 (pIC 50 ). Specification: 10mM in DMSO Molecular Formula: C19H20Cl2FN3O4S Molecular Weight: 476.35

UPC:

51144119

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C654822-1ml

CAS:

1873376-49-8

Product Size:

1ml