Dansylcadaverine

Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Specifications & Purity: Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

MDL Number: MFCD00042704

Molecular Formula: C17H25N3O2S

Molecular Weight: 335.46

EC Number: 233-326-9

PubChem CID: 4247

Isomeric SMILES: CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NCCCCCN

Beilstein: 2951070

Storage Temperature: Store at -20°C;Argon charged

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D131032-SCI_201b7d4867dba1bf542f5e8c9bc1c294.pdf

UPC:

51152109

Weight:

1.23 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

D131032-5g

Country of Origin:

China

CAS:

10121-91-2

Product Size:

5g

Harmonized Tariff Code:

2904.10.50

Hazard Statement Codes:

H315;H319;H335

Precautionary Statement Codes:

P261;P264;P271;P280;P321;P302+P352;P304+P340;P305+P351+P338;P362+P364;P405;P403+P233;P501;P264+P265;P337+P317;P332+P317;P319